Peroxisome proliferator-activated receptor gamma (PPARγ)

URI: https://gptkb.org/entity/Peroxisome_proliferator-activated_receptor_gamma_(PPARγ)
GPTKB entity
Statements (55)
Predicate Object
gptkbp:instanceOf transcription factor
nuclear receptor
gptkbp:activatedBy gptkb:pioglitazone
gptkb:rosiglitazone
troglitazone
gptkbp:alternativeName gptkb:NR1C3
peroxisome proliferator-activated receptor gamma
PPAR gamma
gptkbp:associatedWith gptkb:cancer
gptkb:metabolic_syndrome
prostate cancer
colon cancer
lipodystrophy
gptkbp:discoveredBy Bruce M. Spiegelman
gptkbp:encodedBy PPARG gene
gptkbp:Entrez_Gene_ID 5468
gptkbp:expressedIn adipose tissue
colon
macrophages
immune cells
gptkbp:firstDescribed 1994
gptkbp:formsHeterodimerWith gptkb:retinoid_X_receptor_(RXR)
gptkbp:gene gptkb:PPARG
gptkbp:hasIsoform PPARγ1
PPARγ2
PPARγ3
gptkbp:HGNC_ID 9236
https://www.w3.org/2000/01/rdf-schema#label Peroxisome proliferator-activated receptor gamma (PPARγ)
gptkbp:inhibitedBy phosphorylation
gptkbp:involves obesity
atherosclerosis
inflammation
type 2 diabetes treatment
gptkbp:ligand gptkb:thiazolidinediones
prostaglandins
fatty acids
gptkbp:locatedOnChromosome gptkb:chromosome_3p25
gptkbp:member nuclear hormone receptor superfamily
gptkbp:modulatedBy apoptosis
cell differentiation
inflammatory response
gptkbp:OMIM 601487
gptkbp:PDB 3CS8
gptkbp:phosphorylates gptkb:MAPK
gptkbp:regulates lipid metabolism
glucose metabolism
insulin sensitivity
adipogenesis
gptkbp:target antidiabetic drugs
gptkbp:UniProtID P37231
gptkbp:bfsParent gptkb:4EZP
gptkb:5TBU
gptkb:5HYN
gptkb:PDB_1LDS
gptkbp:bfsLayer 8