|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PKNOX1
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
developmental disorders
|
|
gptkbp:conservedIn
|
vertebrates
|
|
gptkbp:discoveredBy
|
researchers studying homeobox genes
|
|
gptkbp:domain
|
homeodomain
|
|
gptkbp:encodedBy
|
gptkb:PBX/knotted_1_homeobox_1_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000154734
|
|
gptkbp:expressedIn
|
various tissues
hematopoietic cells
embryonic stem cells
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:formsComplexWith
|
gptkb:MEIS_proteins
gptkb:PBX_proteins
|
|
gptkbp:fullName
|
gptkb:proline-rich_nuclear_receptor_coactivator_1
|
|
gptkbp:function
|
transcription factor
regulates gene expression
|
|
gptkbp:gene
|
gptkb:PREP1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:9022
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PREP1
|
|
gptkbp:interactsWith
|
gptkb:PBX1
gptkb:MEIS1
|
|
gptkbp:length
|
436 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
21q22.3
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental defects
impaired hematopoiesis
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:proteinFamily
|
gptkb:TALE_homeobox_family
|
|
gptkbp:regulates
|
gptkb:Hox_genes
phosphorylation
protein-protein interactions
cell cycle genes
apoptosis-related genes
target genes via DNA binding
|
|
gptkbp:role
|
apoptosis
cell differentiation
embryonic development
tumor suppression
hematopoiesis
|
|
gptkbp:structure
|
contains homeodomain and proline-rich regions
|
|
gptkbp:UniProtID
|
O15550
|
|
gptkbp:bfsParent
|
gptkb:PBX1
|
|
gptkbp:bfsLayer
|
6
|