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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alternativeName
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gptkb:phosphoinositide-3-kinase_catalytic_subunit_gamma
PI3KCG
p110-gamma
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gptkbp:associatedWith
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gptkb:cancer
asthma
rheumatoid arthritis
|
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gptkbp:biologicalProcess
|
cell proliferation
cell survival
signal transduction
kinase activity
ATP binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
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gptkbp:cellularComponent
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gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:discoveredBy
|
Yano et al., 1998
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gptkbp:encodes
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gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000105851
5294
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gptkbp:expressedIn
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gptkb:leukocytes
gptkb:cancer
heart
|
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gptkbp:function
|
catalytic subunit of class I PI3K gamma
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gptkbp:geneType
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protein-coding
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gptkbp:HGNC_ID
|
8977
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CG (human)
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gptkbp:interactsWith
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gptkb:RAS_proteins
G-protein beta-gamma subunits
P101 regulatory subunit (PIK3R5)
P84 regulatory subunit (PIK3R6)
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gptkbp:involvedIn
|
cell migration
immune response
inflammatory response
phosphoinositide 3-kinase signaling pathway
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gptkbp:length
|
1102 amino acids
|
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gptkbp:locatedOnChromosome
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gptkb:chromosome_7
7q22.3
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gptkbp:molecularWeight
|
124 kDa
|
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gptkbp:OMIM
|
602838
|
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gptkbp:organism
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gptkb:Homo_sapiens
|
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gptkbp:orthologInMouse
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gptkb:Pik3cg
|
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gptkbp:phosphorylates
|
phosphatidylinositol-4,5-bisphosphate
|
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gptkbp:produces
|
phosphatidylinositol-3,4,5-trisphosphate
|
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gptkbp:product
|
gptkb:PI3K_gamma
|
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gptkbp:RefSeq
|
NM_002649
|
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gptkbp:regulates
|
chemotaxis
inflammatory cell recruitment
|
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gptkbp:target
|
pharmacological inhibitors (e.g., AS-605240)
|
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gptkbp:UniProtID
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gptkb:P48736
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gptkbp:bfsParent
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gptkb:Pik3cg
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gptkbp:bfsLayer
|
6
|