PI3-kinase regulatory subunit beta

URI: https://gptkb.org/entity/PI3-kinase_regulatory_subunit_beta
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:p85β
gptkb:p85-beta
gptkb:phosphoinositide-3-kinase_regulatory_subunit_2
gptkbp:associatedWith gptkb:megalencephaly-polymicrogyria-polydactyly-hydrocephalus_syndrome
overgrowth syndromes
gptkbp:biologicalProcess phosphatidylinositol 3-kinase regulatory activity
gptkbp:Entrez_Gene_ID ENSG00000105647
GC19P041073
gptkbp:expressedIn various tissues
gptkbp:firstDescribed 1995
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulatory subunit of phosphoinositide 3-kinase
gptkbp:gene gptkb:PIK3R2
gptkbp:HGNC_ID 8975
https://www.w3.org/2000/01/rdf-schema#label PI3-kinase regulatory subunit beta
gptkbp:interactsWith gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:IRS1
gptkbp:involves gptkb:PI3K-Akt_signaling_pathway
gptkbp:length 728
gptkbp:locatedOnChromosome gptkb:19p13.1
gptkbp:molecularWeight 83 kDa
gptkbp:mutationAssociatedWith developmental disorders
megalencephaly syndromes
gptkbp:OMIM 603157
gptkbp:orthologInMouse gptkb:Pik3r2
gptkbp:participatedIn cell survival
metabolism
cell growth
insulin signaling
gptkbp:phosphorylates tyrosine residues
gptkbp:RefSeq NM_005027
gptkbp:regulates PI3K catalytic activity
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:structure contains SH2 domains
contains BCR homology domain
contains SH3 domain
gptkbp:subcellularLocation gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:target therapeutic antibodies
small molecule inhibitors
gptkbp:UniProtID O00459
gptkbp:bfsParent gptkb:PIK3R2
gptkbp:bfsLayer 6