|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
cholesterol
|
|
gptkbp:alsoKnownAs
|
gptkb:cholesterol_7_alpha-hydroxylase
|
|
gptkbp:catalyzes
|
conversion of cholesterol to 7-alpha-hydroxycholesterol
|
|
gptkbp:cofactor
|
gptkb:cytochrome_P450_reductase
NADPH
|
|
gptkbp:EC_number
|
1.14.14.23
|
|
gptkbp:expressedIn
|
liver
|
|
gptkbp:gene
|
gptkb:CYP7A1
|
|
gptkbp:HGNC_ID
|
2593
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P450 7A1
|
|
gptkbp:inhibitedBy
|
bile acids
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
8q11-q12
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_hypercholesterolemia
gptkb:cerebrotendinous_xanthomatosis
|
|
gptkbp:OMIM
|
118465
|
|
gptkbp:pathway
|
bile acid biosynthesis
|
|
gptkbp:product
|
7-alpha-hydroxycholesterol
|
|
gptkbp:proteinFamily
|
gptkb:cytochrome_P450
|
|
gptkbp:RefSeq
|
gptkb:NM_000780
|
|
gptkbp:regulates
|
regulated by nuclear receptors
regulated by bile acids
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:substrate
|
cholesterol
|
|
gptkbp:UniProtID
|
gptkb:P22680
|
|
gptkbp:bfsParent
|
gptkb:CYP7A1
|
|
gptkbp:bfsLayer
|
6
|