|
gptkbp:instanceOf
|
UniProt accession number
|
|
gptkbp:alternativeName
|
gptkb:CD220
Insulin receptor alpha chain
Insulin receptor beta chain
|
|
gptkbp:amendedBy
|
Phosphorylation
Disulfide bond
Glycosylation
|
|
gptkbp:associatedWith
|
gptkb:Donohue_syndrome
gptkb:Rabson-Mendenhall_syndrome
gptkb:Insulin_resistance
gptkb:Type_2_diabetes_mellitus
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
insulin receptor signaling pathway
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:database
|
gptkb:UniProt
|
|
gptkbp:Entrez_Gene_ID
|
3643
ENSG00000171105
|
|
gptkbp:function
|
Receptor tyrosine kinase involved in insulin signaling
|
|
gptkbp:gene
|
gptkb:INSR
|
|
gptkbp:hasIsoform
|
2
|
|
gptkbp:HGNC_ID
|
6088
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P35520
|
|
gptkbp:InterPro
|
gptkb:IPR000719
IPR015425
IPR016243
|
|
gptkbp:KEGGID
|
hsa:3643
|
|
gptkbp:locatedOnChromosome
|
19
|
|
gptkbp:locusType
|
gptkb:19p13.2
|
|
gptkbp:name
|
INSR_HUMAN
|
|
gptkbp:OMIM
|
147670
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
9606
|
|
gptkbp:PDB
|
6CE9
6HN5
6PXV
6PXW
6SOF
|
|
gptkbp:protein_name
|
gptkb:Insulin_receptor
|
|
gptkbp:proteinFamily
|
gptkb:PF07714
PF00047
|
|
gptkbp:Reactome
|
R-HSA-74751
|
|
gptkbp:refersTo
|
gptkb:Insulin_receptor
|
|
gptkbp:sequence
|
1382
|
|
gptkbp:signalPeptide
|
Present
|
|
gptkbp:status
|
Reviewed
|
|
gptkbp:subunit
|
Tetramer of two alpha and two beta chains
|
|
gptkbp:tissue_specificity
|
Expressed in many tissues, highest in liver, muscle, adipose tissue
|
|
gptkbp:transmembraneDomains
|
Present
|
|
gptkbp:UniGene
|
Hs.654
|
|
gptkbp:UniProtID
|
gptkb:P35520
|
|
gptkbp:bfsParent
|
gptkb:Cystathionine_beta-synthase
|
|
gptkbp:bfsLayer
|
7
|