|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:P2RX7
P2X7R
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
neurodegenerative diseases
inflammation
chronic pain
immune system
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:encodedBy
|
P2RX7 gene
|
|
gptkbp:Entrez_Gene_ID
|
5027
ENSG00000182054
|
|
gptkbp:expressedIn
|
gptkb:microglia
macrophages
lymphocytes
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:P2X_purinoceptor_7
|
|
gptkbp:function
|
ATP-gated ion channel
mediates inflammatory responses
involved in cell death
|
|
gptkbp:HGNC_ID
|
gptkb:P2RX7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P2X7
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
cell lysis
cytokine release
|
|
gptkbp:ligand
|
gptkb:ATP
|
|
gptkbp:locatedOnChromosome
|
12q24
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:modulatedBy
|
antagonists
agonists
|
|
gptkbp:OMIM
|
602566
|
|
gptkbp:orthologIn
|
mouse P2rx7
|
|
gptkbp:PDB
|
5U1X
6U9M
6U9N
6U9O
6U9P
6U9Q
6U9R
6U9S
6U9T
6U9U
6U9V
6U9W
6U9X
6U9Y
6U9Z
|
|
gptkbp:structure
|
trimeric
|
|
gptkbp:UniProtID
|
Q99572
|
|
gptkbp:bfsParent
|
gptkb:P2RX7
|
|
gptkbp:bfsLayer
|
7
|