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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:Amyloid_precursor_protein
gptkb:APPI
PreA4
ABPP
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gptkbp:associatedWith
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gptkb:Alzheimer's_disease
Cerebral amyloid angiopathy
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gptkbp:database
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Ensembl: ENSG00000142192
GeneID: 351
HGNC: 620
OMIM: 104760
PDB: 3UMH
PDB: 5OQV
Reactome: R-HSA-977225
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gptkbp:disulfideBond
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Present
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gptkbp:domain
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E2 domain
Kunitz-type protease inhibitor domain
A4 domain
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gptkbp:enzymeCleavage
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Alpha-secretase
Beta-secretase
Gamma-secretase
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gptkbp:function
|
Precursor of amyloid beta peptide
Involved in neuronal growth, survival, and post-injury repair
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gptkbp:gene
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gptkb:APP
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gptkbp:hasIsoform
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gptkb:APP695
gptkb:APP751
gptkb:APP770
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https://www.w3.org/2000/01/rdf-schema#label
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P08559
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gptkbp:length
|
770 amino acids
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gptkbp:locatedOnChromosome
|
21
21q21.3
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gptkbp:molecularWeight
|
87,997 Da
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gptkbp:mutationAssociatedWith
|
Mutations cause familial Alzheimer's disease
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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Mus musculus App
Rattus norvegicus App
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gptkbp:postTranslationalModification
|
Glycosylated
Phosphorylated
Palmitoylated
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gptkbp:protein_name
|
gptkb:Amyloid_beta_A4_protein
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gptkbp:sequenceStatus
|
Reviewed
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gptkbp:signalPeptide
|
Present
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gptkbp:subcellularLocation
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gptkb:Endosome
gptkb:Cell_membrane
gptkb:Golgi_apparatus
gptkb:Endoplasmic_reticulum
Secreted
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gptkbp:tissue_specificity
|
Expressed in brain
Expressed in many tissues
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gptkbp:transmembraneDomains
|
Present
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gptkbp:UniProtID
|
gptkb:P08559
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gptkbp:bfsParent
|
gptkb:PDHA1
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gptkbp:bfsLayer
|
7
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