ODC1

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias gptkb:ODC
ODC-1
ornithine carboxylase
gptkbp:associatedWith gptkb:neuroblastoma
gptkb:cancer
ornithine decarboxylase deficiency
gptkbp:biologicalProcess polyamine biosynthetic process
gptkbp:discoveredBy J.M. Morris et al.
gptkbp:encodes gptkb:ornithine_decarboxylase
gptkbp:Entrez_Gene_ID 4953
ENSG00000115758
gptkbp:enzymeCommissionNumber 4.1.1.17
gptkbp:expressedIn many tissues
gptkbp:expressionRegulation rapidly degraded
gptkbp:fullName ornithine decarboxylase 1
gptkbp:function catalyzes the decarboxylation of ornithine to putrescine
gptkbp:geneLocationEnd 8811227
gptkbp:geneLocationStart 8795742
gptkbp:geneType protein-coding
gptkbp:GOID GO:0004586
gptkbp:hasTranscriptVariant multiple
gptkbp:HGNC_ID HGNC:8106
https://www.w3.org/2000/01/rdf-schema#label ODC1
gptkbp:inhibitedBy difluoromethylornithine (DFMO)
gptkbp:length 461 amino acids
gptkbp:locatedOnChromosome gptkb:2p25
gptkbp:molecularWeight 53 kDa
gptkbp:mutationAssociatedWith can cause intellectual disability
can cause developmental delay
gptkbp:OMIM 165640
gptkbp:orthologInMouse Odc1
gptkbp:pathway gptkb:urea_cycle
polyamine biosynthesis
gptkbp:PDB 1D7K
gptkbp:product homodimer
gptkbp:proteinFamily Orn/Lys/Arg decarboxylase family
pyridoxal phosphate binding domain
gptkbp:referenceGenome gptkb:GRCh38
gptkbp:regulates gptkb:MYC
polyamines
antizyme
rate-limiting enzyme in polyamine synthesis
gptkbp:significance pathogenic variants reported
gptkbp:strand plus
gptkbp:subcellularLocation gptkb:cytoplasm
gptkbp:tissue_specificity ubiquitous
gptkbp:UniProtID P11926
gptkbp:bfsParent gptkb:ornithine_decarboxylase
gptkb:ODC
gptkb:MMYC
gptkbp:bfsLayer 8