|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ODC
ODC-1
ornithine carboxylase
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:cancer
ornithine decarboxylase deficiency
|
|
gptkbp:biologicalProcess
|
polyamine biosynthetic process
|
|
gptkbp:discoveredBy
|
J.M. Morris et al.
|
|
gptkbp:encodes
|
gptkb:ornithine_decarboxylase
|
|
gptkbp:Entrez_Gene_ID
|
4953
ENSG00000115758
|
|
gptkbp:enzymeCommissionNumber
|
4.1.1.17
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:expressionRegulation
|
rapidly degraded
|
|
gptkbp:fullName
|
ornithine decarboxylase 1
|
|
gptkbp:function
|
catalyzes the decarboxylation of ornithine to putrescine
|
|
gptkbp:geneLocationEnd
|
8811227
|
|
gptkbp:geneLocationStart
|
8795742
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
GO:0004586
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:8106
|
|
gptkbp:inhibitedBy
|
difluoromethylornithine (DFMO)
|
|
gptkbp:length
|
461 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:2p25
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause intellectual disability
can cause developmental delay
|
|
gptkbp:OMIM
|
165640
|
|
gptkbp:orthologInMouse
|
Odc1
|
|
gptkbp:pathway
|
gptkb:urea_cycle
polyamine biosynthesis
|
|
gptkbp:PDB
|
1D7K
|
|
gptkbp:product
|
homodimer
|
|
gptkbp:proteinFamily
|
Orn/Lys/Arg decarboxylase family
pyridoxal phosphate binding domain
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:MYC
polyamines
antizyme
rate-limiting enzyme in polyamine synthesis
|
|
gptkbp:significance
|
pathogenic variants reported
|
|
gptkbp:strand
|
plus
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P11926
|
|
gptkbp:bfsParent
|
gptkb:ornithine_decarboxylase
gptkb:ODC
gptkb:MMYC
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ODC1
|