|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:POU5F1
Octamer-binding transcription factor 4
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:downregulatedDuring
|
differentiation
|
|
gptkbp:encodes
|
gptkb:OCT4_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000204531
5460
|
|
gptkbp:expressedIn
|
gptkb:germ_cells
embryonic stem cells
pre-implantation embryogenesis
|
|
gptkbp:function
|
transcriptional regulation
regulation of pluripotency
|
|
gptkbp:hasIsoform
|
OCT4A
OCT4B
OCT4B1
|
|
gptkbp:HGNC_ID
|
9211
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OCT4 gene
|
|
gptkbp:involvedIn
|
induced pluripotent stem cell generation
|
|
gptkbp:length
|
360 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
6p21.33
|
|
gptkbp:marking
|
pluripotency
stem cell identification
|
|
gptkbp:memberOf
|
POU family of transcription factors
|
|
gptkbp:molecularWeight
|
38 kDa
|
|
gptkbp:mutationAssociatedWith
|
testicular cancer
germ cell tumors
|
|
gptkbp:OMIM
|
164177
|
|
gptkbp:orthologInMouse
|
Pou5f1
|
|
gptkbp:proteinFamily
|
gptkb:POU-specific_domain
gptkb:POU_homeodomain
|
|
gptkbp:regulates
|
gptkb:FGF4_gene
gptkb:SOX2_gene
gptkb:NANOG_gene
transcriptional repressor
transcriptional activator
octamer motif (ATGCAAAT)
self-renewal of stem cells
cell fate decisions
UTF1 gene
differentiation of stem cells
gene expression in pluripotent cells
|
|
gptkbp:requires
|
early embryonic development
|
|
gptkbp:UniProtID
|
gptkb:Q01860
|
|
gptkbp:upregulatedBy
|
germ cell tumors
|
|
gptkbp:usedIn
|
reprogramming somatic cells
|
|
gptkbp:bfsParent
|
gptkb:SOX2_gene
|
|
gptkbp:bfsLayer
|
7
|