|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_delta_isoform
|
|
gptkbp:associatedWith
|
gptkb:immunodeficiency_14
activated PI3K-delta syndrome (APDS)
|
|
gptkbp:biologicalProcess
|
signal transduction
immune response
kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
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gptkbp:database
|
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:UniProt
gptkb:Ensembl
|
|
gptkbp:Entrez_Gene_ID
|
5293
ENSG00000171608
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.1.153
|
|
gptkbp:function
|
catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate
|
|
gptkbp:gene
|
gptkb:PIK3CD
|
|
gptkbp:HGNC_ID
|
8977
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
O00329 (PIK3CD)
|
|
gptkbp:interactsWith
|
gptkb:GAB2
gptkb:SH3KBP1
p85 regulatory subunit
|
|
gptkbp:length
|
1044 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.22
|
|
gptkbp:molecularWeight
|
119 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus_Pik3cd
gptkb:Rattus_norvegicus_Pik3cd
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:phosphorylates
|
gptkb:Serine_1101
gptkb:Tyrosine_524
|
|
gptkbp:RefSeq
|
gptkb:NP_005017.2
|
|
gptkbp:sequenceStatus
|
reviewed
|
|
gptkbp:subunit
|
heterodimer with regulatory subunit
|
|
gptkbp:targetOfDrug
|
gptkb:duvelisib
gptkb:idelalisib
gptkb:umbralisib
|
|
gptkbp:tissue_specificity
|
gptkb:leukocytes
lymphoid tissues
|
|
gptkbp:UniProtID
|
O00329
|
|
gptkbp:bfsParent
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|