Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:neurofibromin
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:domain |
gptkb:GRD_(GAP-related_domain)
gptkb:PH-like_domain Sec14 domain |
| gptkbp:encodedBy |
gptkb:NF1_gene
|
| gptkbp:function |
gptkb:Ras_GTPase-activating_protein
tumor suppressor |
| https://www.w3.org/2000/01/rdf-schema#label |
Nf1 protein
|
| gptkbp:interactsWith |
gptkb:Ras_proteins
gptkb:SPRED1 microtubules |
| gptkbp:involvedIn |
regulation of Ras signaling pathway
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
~320 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:neurofibromatosis_type_1
tumor formation increased Ras activity |
| gptkbp:OMIM |
613113
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:regulates |
cell differentiation
cell proliferation cell migration learning and memory |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:UniProtID |
P21359
|
| gptkbp:bfsParent |
gptkb:NF1_protein
|
| gptkbp:bfsLayer |
7
|