Neural Cell Adhesion Molecule 1

URI: https://gptkb.org/entity/Neural_Cell_Adhesion_Molecule_1

GPTKB entity

Statements (89)

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:NCAM1
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:associatedWith	gptkb:Alzheimer's_disease bipolar disorder schizophrenia
gptkbp:cellularComponent	gptkb:cell_membrane gptkb:plasma_membrane
gptkbp:discoveredBy	1980s
gptkbp:expressedIn	gptkb:breast gptkb:cervix gptkb:endometrium gptkb:fallopian_tube gptkb:gallbladder gptkb:cancer gptkb:bone gptkb:skin gptkb:pituitary_gland gptkb:skeletal_muscle gptkb:adrenal_gland gptkb:kidney gptkb:placenta gptkb:prostate gptkb:small_intestine gptkb:spinal_cord gptkb:testis gptkb:thymus gptkb:pancreatic_islets heart retina central nervous system liver collagen spleen adipose tissue bladder bone marrow colon esophagus lymph node pancreas peripheral nervous system salivary gland stomach thyroid gland umbilical cord placental villi fetal liver fetal muscle fetal adrenal gland fetal brain fetal heart fetal intestine fetal kidney fetal lung fetal ovary fetal pancreas fetal spleen fetal testis fetal thymus
gptkbp:extracellular_domains	2 fibronectin type III domains 5 Ig-like domains
gptkbp:foundIn	gptkb:skeletal_muscle neurons glial cells
gptkbp:function	gptkb:synaptic_plasticity neuronal development cell adhesion
gptkbp:gene	gptkb:NCAM1
gptkbp:HGNC_ID	7667
https://www.w3.org/2000/01/rdf-schema#label	Neural Cell Adhesion Molecule 1
gptkbp:interactsWith	gptkb:L1CAM fibroblast growth factor receptor NCAM2
gptkbp:locatedOnChromosome	gptkb:chromosome_11q23.1 gptkb:11q23.1
gptkbp:molecularWeight	120-180 kDa
gptkbp:OMIM	116930
gptkbp:orthologInMouse	Ncam1
gptkbp:postTranslationalModification	polysialylation
gptkbp:role	neurite outgrowth learning and memory axon guidance synapse formation
gptkbp:species	gptkb:Homo_sapiens
gptkbp:structure	gptkb:immunoglobulin_superfamily
gptkbp:UniProtID	P13591
gptkbp:bfsParent	gptkb:CD56
gptkbp:bfsLayer	7