Nerve Growth Factor (NGF)

URI: https://gptkb.org/entity/Nerve_Growth_Factor_(NGF)
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
neurotrophin
gptkbp:alternativeName gptkb:NGF
gptkb:beta-NGF
gptkbp:associatedWith gptkb:hereditary_sensory_and_autonomic_neuropathy_type_IV
gptkb:hereditary_sensory_and_autonomic_neuropathy_type_V
gptkbp:biologicalProcess cell differentiation
cell survival
neurogenesis
apoptosis regulation
gptkbp:category growth factor
signaling molecule
gptkbp:clinicalTrialPhase studied for peripheral neuropathy
studied for Alzheimer's disease
gptkbp:discoveredBy gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
gptkbp:discoveredIn 1950s
gptkbp:encodedBy NGF gene
gptkbp:expressedIn central nervous system
peripheral tissues
gptkbp:firstIsolatedFrom mouse sarcoma
gptkbp:foundIn humans
mammals
gptkbp:function promotes growth and survival of neurons
regulates differentiation of neurons
gptkbp:gene gptkb:NGF
gptkbp:hasTherapeuticUse potential treatment for neurodegenerative diseases
https://www.w3.org/2000/01/rdf-schema#label Nerve Growth Factor (NGF)
gptkbp:inducedBy differentiation of PC12 cells
gptkbp:locatedOnChromosome gptkb:1p13.1
gptkbp:molecularWeight ~26 kDa
gptkbp:NobelPrizeYear Rita Levi-Montalcini and Stanley Cohen won Nobel Prize in Physiology or Medicine 1986 for NGF discovery
gptkbp:OMIM 162030
gptkbp:PDB gptkb:1BET
gptkbp:promotion neurite outgrowth
gptkbp:recipient gptkb:TrkA
gptkb:p75NTR
gptkbp:regulates gptkb:synaptic_plasticity
axon growth
neuronal survival
gptkbp:relatedTo gptkb:Alzheimer's_disease
pain modulation
peripheral nervous system
gptkbp:sequence gptkb:protein
gptkbp:structure homodimer
gptkbp:UniProtID gptkb:P01138
gptkbp:bfsParent gptkb:NGF_protein_complex
gptkbp:bfsLayer 8