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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
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gptkb:CD10
neutral endopeptidase
CALLA
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gptkbp:associatedWith
|
gptkb:leukemia
gptkb:Alzheimer's_disease
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gptkbp:biologicalProcess
|
regulation of blood pressure
peptide catabolic process
neuropeptide catabolic process
|
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gptkbp:cellularComponent
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gptkb:plasma_membrane
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gptkbp:discoveredBy
|
Almenoff and Orlowski
|
|
gptkbp:discoveredIn
|
1979
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gptkbp:EC_number
|
3.4.24.11
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gptkbp:function
|
degrades amyloid beta peptide
degrades enkephalins
degrades natriuretic peptides
degrades substance P
cleaves peptides at the amino side of hydrophobic residues
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gptkbp:gene
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gptkb:MME
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gptkbp:GO_term
|
GO:0004222
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gptkbp:inhibitedBy
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gptkb:sacubitril
thiorphan
racecadotril
|
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gptkbp:locatedOnChromosome
|
human chromosome 3q25
|
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gptkbp:location
|
gptkb:cancer
gptkb:cell_membrane
gptkb:kidney
gptkb:small_intestine
brain
liver
neutrophils
|
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gptkbp:molecularWeight
|
approximately 100 kDa
|
|
gptkbp:OMIM
|
120520
|
|
gptkbp:PDB
|
1DMT
1R1H
1R1I
|
|
gptkbp:significance
|
marker for acute lymphoblastic leukemia
target for heart failure therapy
|
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gptkbp:structure
|
zinc-dependent metalloprotease
|
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gptkbp:substrate
|
gptkb:gastrin
gptkb:somatostatin
gptkb:angiotensin_I
gptkb:bradykinin
gptkb:neurotensin
gptkb:oxytocin
atrial natriuretic peptide
insulin B chain
C-type natriuretic peptide
brain natriuretic peptide
|
|
gptkbp:UniProtID
|
P08473
|
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gptkbp:bfsParent
|
gptkb:MME
|
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Neprilysin
|