Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:CD10
neutral endopeptidase CALLA |
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
leukemia |
| gptkbp:biologicalProcess |
regulation of blood pressure
peptide catabolic process neuropeptide catabolic process |
| gptkbp:cellularComponent |
gptkb:plasma_membrane
|
| gptkbp:discoveredBy |
Almenoff and Orlowski
|
| gptkbp:discoveredIn |
1979
|
| gptkbp:EC_number |
3.4.24.11
|
| gptkbp:function |
degrades amyloid beta peptide
degrades enkephalins degrades natriuretic peptides degrades substance P cleaves peptides at the amino side of hydrophobic residues |
| gptkbp:gene |
gptkb:MME
|
| gptkbp:GO_term |
GO:0004222
|
| https://www.w3.org/2000/01/rdf-schema#label |
Neprilysin
|
| gptkbp:inhibitedBy |
gptkb:sacubitril
thiorphan racecadotril |
| gptkbp:locatedOnChromosome |
human chromosome 3q25
|
| gptkbp:location |
gptkb:cancer
gptkb:cell_membrane gptkb:kidney gptkb:small_intestine brain liver neutrophils |
| gptkbp:molecularWeight |
approximately 100 kDa
|
| gptkbp:OMIM |
120520
|
| gptkbp:PDB |
1DMT
1R1H 1R1I |
| gptkbp:significance |
marker for acute lymphoblastic leukemia
target for heart failure therapy |
| gptkbp:structure |
zinc-dependent metalloprotease
|
| gptkbp:substrate |
gptkb:gastrin
gptkb:somatostatin gptkb:angiotensin_I gptkb:bradykinin gptkb:neurotensin gptkb:oxytocin atrial natriuretic peptide insulin B chain C-type natriuretic peptide brain natriuretic peptide |
| gptkbp:UniProtID |
P08473
|
| gptkbp:bfsParent |
gptkb:MME
|
| gptkbp:bfsLayer |
6
|