|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:NT-3
gptkb:Neurotrophin-3
|
|
gptkbp:associatedWith
|
neurodegenerative diseases
developmental disorders
neurological disorders
|
|
gptkbp:binds
|
gptkb:p75NTR_receptor
gptkb:TrkC_receptor
|
|
gptkbp:biologicalProcess
|
gptkb:synaptic_plasticity
cell differentiation
cell survival
growth factor activity
axon guidance
receptor binding
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
gptkb:NTF3_gene
|
|
gptkbp:Entrez_Gene_ID
|
4908
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
brain
heart
peripheral nervous system
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
growth factor
promotes survival and differentiation of neurons
|
|
gptkbp:GO_term
|
gptkb:GO:0007267
GO:0008083
GO:0030182
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTF3 protein
|
|
gptkbp:involvedIn
|
nervous system development
neuronal differentiation
neuronal survival
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12p13
|
|
gptkbp:memberOf
|
neurotrophin family
|
|
gptkbp:molecularWeight
|
~27 kDa
|
|
gptkbp:OMIM
|
162645
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1BET
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:sequence
|
257 amino acids
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:UniProtID
|
P20783
|
|
gptkbp:bfsParent
|
gptkb:NT-3
|
|
gptkbp:bfsLayer
|
7
|