Statements (87)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
transcription factor
|
| gptkbp:alsoKnownAs |
NFE2L1
Nuclear factor erythroid 2-related factor 1 |
| gptkbp:encodedBy |
NFE2L1 gene
|
| gptkbp:function |
regulation of gene expression
oxidative stress response cellular homeostasis |
| gptkbp:gene |
NFE2L1
|
| https://www.w3.org/2000/01/rdf-schema#label |
NF-E1
|
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
17q21.3
|
| gptkbp:memberOf |
CNC-bZIP transcription factor family
|
| gptkbp:regulates |
gptkb:superoxide_dismutase
gptkb:matrix_metalloproteinases gptkb:tumor_necrosis_factor_alpha_(TNF-α) apoptosis cell differentiation cell survival lipid metabolism mitochondrial function glucose metabolism developmental processes inflammatory response cellular response to oxidative stress catalase ubiquitin-proteasome system cell cycle genes inflammatory cytokines endoplasmic reticulum stress response chemokines glucose transporter genes heme oxygenase 1 (HMOX1) DNA repair genes gluconeogenesis genes immune response genes antioxidant enzymes glutathione S-transferase glutathione peroxidase thioredoxin reductase ER-associated degradation genes NAD(P)H quinone dehydrogenase 1 (NQO1) TCA cycle genes adipogenesis genes angiogenesis-related genes antioxidant response element (ARE)-driven genes astrocyte function genes autophagy-related genes cholesterol metabolism genes detoxification enzymes fatty acid metabolism genes fibrosis-related genes glycolysis genes insulin signaling genes interleukin-1 beta (IL-1β) interleukin-6 (IL-6) lysosomal genes microglial activation genes mitochondrial DNA maintenance genes mitochondrial antioxidant genes mitochondrial apoptosis genes mitochondrial autophagy genes mitochondrial biogenesis genes mitochondrial dynamics genes mitochondrial fission/fusion genes mitochondrial protein import genes mitochondrial quality control genes mitochondrial stress response genes mitochondrial unfolded protein response genes mitophagy genes multidrug resistance proteins myelination genes neuronal differentiation genes neuroprotective genes oxidative phosphorylation genes pentose phosphate pathway genes peroxiredoxin proteasome gene expression synaptic plasticity genes unfolded protein response genes |
| gptkbp:relatedTo |
gptkb:NF-E2
gptkb:Nrf2 |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:UniProtID |
Q14494
|
| gptkbp:bfsParent |
gptkb:YY1
gptkb:GATA_binding_protein_1 |
| gptkbp:bfsLayer |
8
|