|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
gptkb:gp91phox
|
|
gptkbp:associatedWith
|
gptkb:chronic_granulomatous_disease
|
|
gptkbp:cofactor
|
gptkb:FAD
hemoglobin
NADPH
|
|
gptkbp:component
|
gptkb:NADPH_oxidase_complex
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
CYBB gene
|
|
gptkbp:Entrez_Gene_ID
|
1536
|
|
gptkbp:expressedIn
|
gptkb:microglia
macrophages
neutrophils
|
|
gptkbp:formsComplexWith
|
gptkb:Rac2
p22phox
p40phox
p67phox
p47phox
|
|
gptkbp:function
|
generates superoxide by transferring electrons from NADPH to oxygen
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NADPH oxidase 2 (NOX2)
|
|
gptkbp:inhibitedBy
|
apocynin
DPI (diphenyleneiodonium)
|
|
gptkbp:involvedIn
|
innate immune response
respiratory burst
|
|
gptkbp:locatedIn
|
phagocyte membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xp21.1
|
|
gptkbp:molecularWeight
|
91 kDa
|
|
gptkbp:mutationAssociatedWith
|
X-linked chronic granulomatous disease
|
|
gptkbp:OMIM
|
300481
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
6S0K
|
|
gptkbp:product
|
gptkb:superoxide_anion
|
|
gptkbp:role
|
gptkb:cardiovascular_disease
atherosclerosis
cancer progression
diabetes complications
inflammation
autoimmune disease
neurodegeneration
oxidative stress
lung injury
host defense
|
|
gptkbp:substrate
|
oxygen
|
|
gptkbp:subunit
|
phagocyte NADPH oxidase
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P04839
|
|
gptkbp:bfsParent
|
gptkb:CYBB
|
|
gptkbp:bfsLayer
|
7
|