Mantle Cell Lymphoma

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:cancer
Non-Hodgkin lymphoma
gptkbp:affects Lymphatic system
gptkbp:associatedWith gptkb:t(11;14)(q13;q32)_translocation
gptkbp:commonIn Older adults
Males
gptkbp:diagnosedBy Immunohistochemistry
Flow cytometry
Lymph node biopsy
gptkbp:firstDescribed 1976
gptkbp:hasCellMarker gptkb:CD20
gptkb:Cyclin_D1
gptkb:SOX11
CD5
gptkbp:hasPrognosticIndex MIPI (Mantle Cell Lymphoma International Prognostic Index)
gptkbp:hasVariant Blastoid variant
Pleomorphic variant
https://www.w3.org/2000/01/rdf-schema#label Mantle Cell Lymphoma
gptkbp:ICD-10_code gptkb:C83.1
gptkbp:incidence Rare
gptkbp:mayInclude gptkb:Spleen
gptkb:Bone_marrow
gptkb:Gastrointestinal_tract
Peripheral blood
gptkbp:medianSurvival 3-5 years
gptkbp:notableBattle gptkb:Bortezomib
gptkb:Zanubrutinib
Acalabrutinib
Ibrutinib
Lenalidomide
Rituximab
gptkbp:originatedIn gptkb:B_cells
gptkbp:overexpresses gptkb:Cyclin_D1
gptkbp:prognosis Generally poor
gptkbp:riskFactor Immunosuppression
Male gender
Older age
gptkbp:stageName gptkb:Ann_Arbor_staging
gptkbp:subspecies B-cell lymphoma
gptkbp:symptom Fever
Weight loss
Night sweats
Lymphadenopathy
gptkbp:treatment immunotherapy
Chemotherapy
Targeted therapy
Stem cell transplant
gptkbp:WHOClassification Mature B-cell neoplasm
gptkbp:bfsParent gptkb:MCL
gptkbp:bfsLayer 6