|
gptkbp:instanceOf
|
gptkb:cancer
gptkb:Non-Hodgkin_lymphoma
|
|
gptkbp:affects
|
Lymphatic system
|
|
gptkbp:associatedWith
|
gptkb:t(11;14)(q13;q32)_translocation
|
|
gptkbp:commonIn
|
Older adults
Males
|
|
gptkbp:diagnosedBy
|
Immunohistochemistry
Flow cytometry
Lymph node biopsy
|
|
gptkbp:firstDescribed
|
1976
|
|
gptkbp:hasCellMarker
|
gptkb:CD20
gptkb:Cyclin_D1
gptkb:SOX11
CD5
|
|
gptkbp:hasPrognosticIndex
|
MIPI (Mantle Cell Lymphoma International Prognostic Index)
|
|
gptkbp:hasVariant
|
Blastoid variant
Pleomorphic variant
|
|
gptkbp:ICD-10_code
|
gptkb:C83.1
|
|
gptkbp:incidence
|
Rare
|
|
gptkbp:mayInclude
|
gptkb:Spleen
gptkb:Bone_marrow
gptkb:Gastrointestinal_tract
Peripheral blood
|
|
gptkbp:medianSurvival
|
3-5 years
|
|
gptkbp:notableBattle
|
gptkb:Bortezomib
gptkb:Zanubrutinib
Acalabrutinib
Ibrutinib
Lenalidomide
Rituximab
|
|
gptkbp:originatedIn
|
gptkb:B_cells
|
|
gptkbp:overexpresses
|
gptkb:Cyclin_D1
|
|
gptkbp:prognosis
|
Generally poor
|
|
gptkbp:riskFactor
|
Immunosuppression
Male gender
Older age
|
|
gptkbp:stageName
|
gptkb:Ann_Arbor_staging
|
|
gptkbp:subspecies
|
B-cell lymphoma
|
|
gptkbp:symptom
|
Fever
Weight loss
Night sweats
Lymphadenopathy
|
|
gptkbp:treatment
|
gptkb:immunotherapy
Chemotherapy
Targeted therapy
Stem cell transplant
|
|
gptkbp:WHOClassification
|
Mature B-cell neoplasm
|
|
gptkbp:bfsParent
|
gptkb:MCL
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mantle Cell Lymphoma
|