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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:aspartate
arginine
histidine
|
|
gptkbp:alternativeName
|
gptkb:MDH
gptkb:L-malate_dehydrogenase
|
|
gptkbp:catalyzes
|
oxidation of malate to oxaloacetate
|
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gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:cofactor_binding_site
|
gptkb:Rossmann_fold
|
|
gptkbp:discoveredBy
|
1950s
|
|
gptkbp:EC_number
|
1.1.1.37
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:gene
|
gptkb:MDH1
gptkb:MDH2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Malate dehydrogenase
|
|
gptkbp:inhibitedBy
|
oxaloacetate (product inhibition)
|
|
gptkbp:involves
|
gptkb:malate-aspartate_shuttle
citric acid cycle
|
|
gptkbp:isozyme
|
gptkb:cytosolic_malate_dehydrogenase
gptkb:mitochondrial_malate_dehydrogenase
|
|
gptkbp:molecularWeight
|
~35 kDa (per subunit)
|
|
gptkbp:mutationAssociatedWith
|
metabolic disorders
|
|
gptkbp:optimum_pH
|
7.5
|
|
gptkbp:PDB
|
gptkb:1MLD
gptkb:4MDH
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
fungi
plants
|
|
gptkbp:product
|
gptkb:H+
gptkb:NADH
gptkb:oxaloacetate
|
|
gptkbp:reaction_direction
|
reversible
|
|
gptkbp:relatedTo
|
gptkb:lactate_dehydrogenase
gptkb:isocitrate_dehydrogenase
|
|
gptkbp:requires
|
aerobic respiration
amino acid metabolism
gluconeogenesis
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
malate
|
|
gptkbp:systematicName
|
gptkb:(S)-malate:NAD+_oxidoreductase
|
|
gptkbp:used_in
|
clinical diagnostics
biochemical assays
enzyme-linked assays
|
|
gptkbp:usedFor
|
marker enzyme
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|