Major Histocompatibility Complex molecule
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:MHC_molecule
|
| gptkbp:binds |
peptide antigen
|
| gptkbp:component |
gptkb:adaptive_immune_system
|
| gptkbp:discoveredBy |
1970s
|
| gptkbp:encodedBy |
gptkb:MHC_gene
|
| gptkbp:expressed_by |
antigen-presenting cells (class II)
most nucleated cells (class I) |
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
antigen presentation
|
| gptkbp:hasPolymorphism |
true
|
| https://www.w3.org/2000/01/rdf-schema#label |
Major Histocompatibility Complex molecule
|
| gptkbp:importantFor |
organ transplantation
autoimmune disease |
| gptkbp:involves |
immune response
|
| gptkbp:location |
cell surface
|
| gptkbp:presentedBy |
gptkb:CD4+_T_cell
gptkb:CD8+_T_cell cell surface receptor |
| gptkbp:recognizedBy |
natural killer cell
|
| gptkbp:requires |
self/non-self recognition
|
| gptkbp:species_variant |
gptkb:H-2_(mouse)
HLA (human) |
| gptkbp:structure |
heterodimer
|
| gptkbp:type |
MHC class II molecule
MHC class I molecule MHC class III molecule |
| gptkbp:bfsParent |
gptkb:MHC_molecule
|
| gptkbp:bfsLayer |
6
|