|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ABCC1
gptkb:Multidrug_resistance_protein_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
chemotherapy resistance
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
gptkb:ABCC1_gene
|
|
gptkbp:Entrez_Gene_ID
|
4363
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:fullName
|
gptkb:Multidrug_resistance-associated_protein_1
|
|
gptkbp:function
|
transports organic anions and drugs out of cells
contributes to multidrug resistance in cancer
|
|
gptkbp:gene
|
gptkb:ABCC1
|
|
gptkbp:HGNC_ID
|
HGNC:53
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MRP-1
|
|
gptkbp:locatedOnChromosome
|
16p13.1
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:ABCC_subfamily
gptkb:ATP-binding_cassette_transporter_family
|
|
gptkbp:OMIM
|
158343
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
5UJ9
|
|
gptkbp:structure
|
contains multiple transmembrane domains
contains two nucleotide-binding domains
|
|
gptkbp:substrate
|
gptkb:leukotriene_C4
antineoplastic drugs
glutathione conjugates
organic anions
|
|
gptkbp:UniProtID
|
P33527
|
|
gptkbp:bfsParent
|
gptkb:CD9
|
|
gptkbp:bfsLayer
|
8
|