|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:MPO
peroxidase, myeloid-specific
verdoperoxidase
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
atherosclerosis
myeloperoxidase deficiency
|
|
gptkbp:catalyzes
|
formation of hypochlorous acid from hydrogen peroxide and chloride ions
|
|
gptkbp:color
|
green
|
|
gptkbp:contains
|
heme group
|
|
gptkbp:discoveredBy
|
Allan H. Redfield
|
|
gptkbp:discoveredIn
|
1941
|
|
gptkbp:EC_number
|
1.11.2.2
|
|
gptkbp:Enzyme_Commission_family
|
oxidoreductase
|
|
gptkbp:expressed_during
|
myeloid differentiation
|
|
gptkbp:expressedIn
|
bone marrow
|
|
gptkbp:foundIn
|
monocytes
neutrophil granulocytes
|
|
gptkbp:gene
|
gptkb:MPO
|
|
gptkbp:has_clinical_significance
|
marker for inflammation
|
|
gptkbp:has_cofactor
|
hemoglobin
|
|
gptkbp:has_prosthetic_group
|
iron
|
|
gptkbp:hasRole
|
innate immune response
microbial killing
|
|
gptkbp:HGNC_ID
|
gptkb:MPO
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Myeloperoxidase
|
|
gptkbp:inhibitedBy
|
gptkb:4-aminobenzoic_acid_hydrazide
azide
cyanide
|
|
gptkbp:involves
|
oxidative burst
|
|
gptkbp:locale
|
azurophilic granules
|
|
gptkbp:locatedOnChromosome
|
17q23.1
|
|
gptkbp:molecularWeight
|
~150 kDa
|
|
gptkbp:OMIM
|
606989
|
|
gptkbp:PDB
|
gptkb:1CXP
|
|
gptkbp:product
|
hypochlorous acid
hypobromous acid
hypoiodous acid
|
|
gptkbp:RefSeq
|
NM_000250
|
|
gptkbp:structure
|
dimeric protein
|
|
gptkbp:substrate
|
gptkb:chloride_ion
hydrogen peroxide
bromide ion
iodide ion
|
|
gptkbp:target
|
autoantibodies in vasculitis
|
|
gptkbp:UniProtID
|
P05164
|
|
gptkbp:used_as_marker_for
|
myeloid cells
|
|
gptkbp:used_in_diagnosis_of
|
gptkb:acute_myeloid_leukemia
|
|
gptkbp:used_in_histochemistry
|
to identify granulocytes
|
|
gptkbp:bfsParent
|
gptkb:MPO
|
|
gptkbp:bfsLayer
|
5
|