|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:aggregationLeadsTo
|
neurodegeneration
|
|
gptkbp:alternativeName
|
gptkb:tau_protein
|
|
gptkbp:associatedWith
|
gptkb:Pick's_disease
gptkb:Alzheimer's_disease
frontotemporal dementia
|
|
gptkbp:degradedBy
|
autophagy
ubiquitin-proteasome system
|
|
gptkbp:discoveredBy
|
gptkb:Marc_Kirschner
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:MAPT_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000186868
|
|
gptkbp:expressedIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:form
|
neurofibrillary tangles
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
protein binding
microtubule stabilization
microtubule binding
|
|
gptkbp:GOProcess
|
axonogenesis
neuron projection development
|
|
gptkbp:hasIsoform
|
6
|
|
gptkbp:HGNC_ID
|
6893
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPT protein
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
microtubule assembly
neuronal polarity
|
|
gptkbp:locatedOnChromosome
|
17q21.31
|
|
gptkbp:location
|
neurons
axons
|
|
gptkbp:molecularWeight
|
50-75 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:corticobasal_degeneration
gptkb:progressive_supranuclear_palsy
parkinsonism
|
|
gptkbp:OMIM
|
157140
|
|
gptkbp:PDB
|
gptkb:5O3L
|
|
gptkbp:phosphorylates
|
Ser404
Ser202
Ser396
Thr205
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
acetylation
|
|
gptkbp:RefSeq
|
NP_005901.2
|
|
gptkbp:speciesHomolog
|
mouse tau protein
rat tau protein
|
|
gptkbp:structure
|
contains microtubule-binding repeats
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P10636
|
|
gptkbp:bfsParent
|
gptkb:MAPTM
|
|
gptkbp:bfsLayer
|
7
|