|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NIK
HGK
HPK/GCK-like kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
inflammatory diseases
|
|
gptkbp:discoveredBy
|
Yao Z et al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000107968
9448
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
pancreas
|
|
gptkbp:fullName
|
Mitogen-activated protein kinase kinase kinase kinase 4
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell migration
serine/threonine protein kinase activity
involved in MAPK signaling pathway
involved in inflammatory response
|
|
gptkbp:gene
|
gptkb:MAP4K4
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:6862
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP4K4
|
|
gptkbp:inhibitedBy
|
GNE-495
PF-06260933
|
|
gptkbp:locatedOnChromosome
|
6
|
|
gptkbp:location
|
gptkb:6q26
|
|
gptkbp:molecularWeight
|
138 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Map4k4
rat Map4k4
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K4
JNK pathway components
|
|
gptkbp:regulates
|
cell proliferation
cell motility
insulin signaling
inflammatory cytokine production
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
membrane-associated
|
|
gptkbp:UniProtID
|
O95819
|
|
gptkbp:bfsParent
|
gptkb:MAP4K
|
|
gptkbp:bfsLayer
|
8
|