|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:LDH-A
gptkb:LDH-M
cellular lactate dehydrogenase
|
|
gptkbp:catalyzes
|
conversion of pyruvate to lactate
|
|
gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:encodedBy
|
gptkb:LDHA_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134333
GC11P015425
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
erythrocytes
brain (low levels)
heart (low levels)
kidney (low levels)
liver (low levels)
lung (low levels)
ovary (low levels)
pancreas (low levels)
placenta (low levels)
prostate (low levels)
spleen (low levels)
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
|
|
gptkbp:gene
|
gptkb:LDHA
|
|
gptkbp:HGNC_ID
|
6541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lactate Dehydrogenase A
|
|
gptkbp:inhibitedBy
|
gptkb:oxamate
gossypol
|
|
gptkbp:involves
|
glycolysis
anaerobic respiration
|
|
gptkbp:locatedOnChromosome
|
11p15.4
|
|
gptkbp:molecularWeight
|
36 kDa (approximate)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:LDHA_deficiency
glycogen storage disease XI
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:orthologInMouse
|
gptkb:Ldha
|
|
gptkbp:PDB
|
gptkb:4AJP
1I10
|
|
gptkbp:product
|
lactate
|
|
gptkbp:RefSeq
|
NM_005566
|
|
gptkbp:significance
|
elevated in some cancers
marker for tissue damage
|
|
gptkbp:structure
|
homotetramer or heterotetramer
|
|
gptkbp:substrate
|
gptkb:pyruvate
|
|
gptkbp:subunit
|
lactate dehydrogenase tetramer
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:LDDA
|
|
gptkbp:bfsLayer
|
8
|