Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alternativeName |
CD85k
HM18 ILT3 LIR-5 Leukocyte immunoglobulin-like receptor 3 |
| gptkbp:associatedWith |
immune evasion in cancer
|
| gptkbp:domain |
immunoglobulin-like domain
ITIM (immunoreceptor tyrosine-based inhibitory motif) |
| gptkbp:encodes |
LILRB4 protein
|
| gptkbp:Entrez_Gene_ID |
11006
ENSG00000105376 |
| gptkbp:expressedIn |
dendritic cells
macrophages monocytes |
| gptkbp:foundIn |
gptkb:cell_membrane
|
| gptkbp:fullName |
Leukocyte immunoglobulin-like receptor subfamily B member 4
|
| gptkbp:function |
immune regulation
inhibitory receptor |
| gptkbp:gene |
gptkb:LILRB4
|
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
6607
|
| https://www.w3.org/2000/01/rdf-schema#label |
LILRB4
|
| gptkbp:inhibitedBy |
antigen-presenting cell activation
|
| gptkbp:involves |
immunotherapy
negative regulation of immune response myeloid cell function |
| gptkbp:locatedOnChromosome |
19
|
| gptkbp:location |
19q13.4
|
| gptkbp:modulatedBy |
immune response
|
| gptkbp:molecularWeight |
~65 kDa
|
| gptkbp:OMIM |
604810
|
| gptkbp:orthologIn |
present in mammals
|
| gptkbp:regulates |
T cell activation
immune tolerance |
| gptkbp:relatedTo |
gptkb:LILRB1
gptkb:LILRB2 gptkb:LILRB3 gptkb:LILRB5 LILRA family |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
extracellular immunoglobulin-like domains, transmembrane region, cytoplasmic ITIMs
|
| gptkbp:target |
therapeutic antibodies (experimental)
|
| gptkbp:transmembraneDomains |
true
|
| gptkbp:UniProtID |
Q8N423
|
| gptkbp:bfsParent |
gptkb:LILR
|
| gptkbp:bfsLayer |
7
|