|
gptkbp:instanceOf
|
gptkb:protein
ionotropic glutamate receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:category
|
gptkb:cell_membrane
neurotransmitter receptor
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:GRIK1
gptkb:GRIK2
gptkb:GRIK3
gptkb:GRIK4
gptkb:GRIK5
|
|
gptkbp:enemyOf
|
gptkb:CNQX
gptkb:NBQX
gptkb:UBP302
gptkb:kainic_acid
glutamate
domoic acid
|
|
gptkbp:expressedIn
|
gptkb:cerebral_cortex
gptkb:spinal_cord
hippocampus
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
mediates excitatory neurotransmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Kainate receptor
|
|
gptkbp:involves
|
epilepsy
neurodegenerative diseases
pain transmission
|
|
gptkbp:ligand
|
gptkb:kainic_acid
glutamate
|
|
gptkbp:location
|
postsynaptic membrane
presynaptic membrane
|
|
gptkbp:modulatedBy
|
gptkb:synaptic_plasticity
neurotransmitter release
|
|
gptkbp:permeableTo
|
K+
Ca2+
Na+
|
|
gptkbp:proteinFamily
|
glutamate receptor family
|
|
gptkbp:relatedTo
|
gptkb:AMPA_receptor
gptkb:NMDA_receptor
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
gptkb:GRIK1
gptkb:GRIK2
gptkb:GRIK3
gptkb:GRIK4
gptkb:GRIK5
|
|
gptkbp:synonym
|
EAA3 receptor
GLUR5-7 receptor
GluK receptor
|
|
gptkbp:bfsParent
|
gptkb:Glutamate
|
|
gptkbp:bfsLayer
|
6
|