KLF transcription factors

URI: https://gptkb.org/entity/KLF_transcription_factors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:associatedWith	gptkb:cancer gptkb:cardiovascular_disease gptkb:diabetes developmental disorders
gptkbp:binds	GC-rich DNA sequences
gptkbp:discoveredIn	1990s
gptkbp:DNA_binding_motif	gptkb:C2H2-type_zinc_finger
gptkbp:domain	three C2H2 zinc fingers at C-terminus
gptkbp:expressedIn	many tissues
gptkbp:fullName	gptkb:Krüppel-like_factor_transcription_factors
gptkbp:function	apoptosis cell differentiation cell proliferation development regulation of gene expression DNA binding
gptkbp:GO_term	GO:0005634 GO:0003700 GO:0006355
gptkbp:hasMember	gptkb:KLF1 gptkb:KLF10 gptkb:KLF11 gptkb:KLF13 gptkb:KLF14 gptkb:KLF15 gptkb:KLF16 gptkb:KLF2 gptkb:KLF4 gptkb:KLF5 gptkb:KLF6 gptkb:KLF9 gptkb:KLF7 gptkb:KLF12 gptkb:KLF3 gptkb:KLF8
https://www.w3.org/2000/01/rdf-schema#label	KLF transcription factors
gptkbp:orthologIn	invertebrates mammals vertebrates
gptkbp:regulates	metabolism angiogenesis inflammation immune response cell cycle stem cell maintenance adipogenesis epithelial-mesenchymal transition transcription by RNA polymerase II
gptkbp:relatedTo	Sp1 transcription factors
gptkbp:superfamily	zinc finger transcription factors
gptkbp:bfsParent	gptkb:Sp/KLF_transcription_factor_family
gptkbp:bfsLayer	7