Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:lung_Kruppel-like_factor
LKLF |
| gptkbp:associatedWith |
cardiovascular diseases
inflammatory diseases |
| gptkbp:discoveredBy |
gptkb:Dr._Mukesh_Jain
|
| gptkbp:encodes |
Kruppel-like factor 2 protein
|
| gptkbp:Entrez_Gene_ID |
10365
ENSG00000136689 |
| gptkbp:expressedIn |
gptkb:cancer
gptkb:T_cells endothelial cells |
| gptkbp:fullName |
gptkb:Kruppel-like_factor_2
|
| gptkbp:function |
transcription factor
|
| gptkbp:HGNC_ID |
HGNC:6346
|
| https://www.w3.org/2000/01/rdf-schema#label |
KLF2
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:memberOf |
gptkb:Kruppel-like_factor_family
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Klf2
|
| gptkbp:proteinFamily |
gptkb:C2H2-type_zinc_finger
|
| gptkbp:regulates |
apoptosis
cell proliferation angiogenesis inflammation cell cycle arrest vascular development binds GC-rich DNA sequences VCAM-1 expression immune cell migration cell adhesion molecules inflammatory cytokines vascular tone endothelial cell function CCR7 expression CD62L expression ICAM-1 expression L-selectin expression S1PR1 expression T cell egress from thymus T cell quiescence T cell trafficking anti-inflammatory genes eNOS expression monocyte adhesion pro-inflammatory genes thrombomodulin expression |
| gptkbp:UniProtID |
Q9Y5W3
|
| gptkbp:bfsParent |
gptkb:Sp/KLF_transcription_factor_family
gptkb:EWSR1 gptkb:Kruppel-like_factors |
| gptkbp:bfsLayer |
7
|