Junctional Adhesion Molecule-A

URI: https://gptkb.org/entity/Junctional_Adhesion_Molecule-A
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf gptkb:protein
cell surface receptor
gptkbp:alternativeName gptkb:JAM-A
gptkb:CD321
gptkbp:discoveredIn 1998
gptkbp:disulfideBond yes
gptkbp:encodedBy gptkb:F11R_gene
gptkbp:Entrez_Gene_ID 50848
gptkbp:expressedIn platelets
endothelial cells
epithelial cells
gptkbp:foundIn humans
mice
gptkbp:function involved in leukocyte transmigration
mediates cell-cell adhesion
regulates tight junction assembly
gptkbp:glycosylation yes
gptkbp:hasCytoplasmicTail yes
gptkbp:hasExtracellularDomain yes
https://www.w3.org/2000/01/rdf-schema#label Junctional Adhesion Molecule-A
gptkbp:interactsWith gptkb:occludin
gptkb:LFA-1
ZO-1
gptkbp:involvedIn angiogenesis
inflammation
tumor metastasis
gptkbp:locatedOn cell surface
gptkbp:locatedOnChromosome chromosome 1q21.1
gptkbp:memberOf gptkb:immunoglobulin_superfamily
gptkbp:molecularWeight 32 kDa
gptkbp:PDB 1NBQ
gptkbp:significance gptkb:cancer
multiple sclerosis
atherosclerosis
inflammatory bowel disease
gptkbp:transmembraneDomains yes
gptkbp:UniProtID gptkb:Q9Y624
gptkbp:bfsParent gptkb:CD323
gptkbp:bfsLayer 8