|
gptkbp:instanceOf
|
gptkb:drug
gptkb:vitamin_A
|
|
gptkbp:administeredBy
|
fatty food (to increase absorption)
|
|
gptkbp:approvalYear
|
1982
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:D10BA01
|
|
gptkbp:brand
|
gptkb:Accutane
gptkb:Absorica
gptkb:Roaccutane
gptkb:Amnesteem
gptkb:Claravis
gptkb:Myorisan
gptkb:Sotret
gptkb:Zenatane
|
|
gptkbp:CASNumber
|
gptkb:4759-48-2
|
|
gptkbp:chemicalFormula
|
C20H28O2
|
|
gptkbp:contraindication
|
pregnancy
|
|
gptkbp:discoveredBy
|
gptkb:Hoffmann-La_Roche
|
|
gptkbp:eliminationHalfLife
|
10-20 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Isotretinoin
|
|
gptkbp:KEGGID
|
D00179
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
decreases sebum production
reduces sebaceous gland size
regulates cell proliferation
|
|
gptkbp:MeSH_ID
|
D004089
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:monitors
|
liver function tests
lipid profile
pregnancy tests (for women of childbearing age)
|
|
gptkbp:pregnancyCategory
|
X (contraindicated)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL472
5282379
DB00717
|
|
gptkbp:relatedTo
|
gptkb:vitamin_A
gptkb:tretinoin
retinoic acid
|
|
gptkbp:riskManagementProgram
|
iPLEDGE (in the US)
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:depression
birth defects
joint pain
muscle aches
dry skin
increased cholesterol
liver enzyme elevation
nosebleeds
dry lips
increased triglycerides
|
|
gptkbp:UNII
|
80168379AG
|
|
gptkbp:usedFor
|
ichthyosis
rosacea
severe acne
hidradenitis suppurativa
acne vulgaris
cystic acne
nodular acne
some skin cancers
|
|
gptkbp:bfsParent
|
gptkb:Roaccutane
|
|
gptkbp:bfsLayer
|
7
|