|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:administeredBy
|
injection
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:category
|
gptkb:cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Lindenmann
gptkb:Alick_Isaacs
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:encodedBy
|
IFN genes
|
|
gptkbp:example
|
gptkb:interferon_gamma
gptkb:interferon_beta
gptkb:interferon_alpha
interferon lambda
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
immunomodulation
antiviral response
inhibition of cell proliferation
|
|
gptkbp:halfLife
|
several hours
|
|
gptkbp:inducedBy
|
expression of interferon-stimulated genes
|
|
gptkbp:inhibitedBy
|
viral replication
tumor cell growth
|
|
gptkbp:mechanismOfAction
|
activation of immune cells
induction of antiviral proteins
upregulation of MHC molecules
|
|
gptkbp:molecularWeight
|
17-25 kDa
|
|
gptkbp:producedBy
|
gptkb:leukocytes
gptkb:natural_killer_cells
gptkb:T_cells
fibroblasts
epithelial cells
|
|
gptkbp:promotion
|
antigen presentation
macrophage activation
natural killer cell activity
|
|
gptkbp:recipient
|
gptkb:interferon_alpha/beta_receptor
interferon gamma receptor
interferon lambda receptor
|
|
gptkbp:regulates
|
gptkb:immune_response
|
|
gptkbp:sideEffect
|
gptkb:depression
gptkb:anemia
fatigue
flu-like symptoms
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:type
|
Type I interferon
Type II interferon
Type III interferon
|
|
gptkbp:usedFor
|
treatment of hepatitis C
treatment of multiple sclerosis
treatment of hepatitis B
treatment of some cancers
|
|
gptkbp:bfsParent
|
gptkb:L03AB08
gptkb:L03AB13
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Interferons
|