Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:administeredBy |
injection
|
| gptkbp:approvedBy |
gptkb:FDA
|
| gptkbp:category |
cytokine
|
| gptkbp:discoveredBy |
gptkb:Jean_Lindenmann
gptkb:Alick_Isaacs |
| gptkbp:discoveredIn |
1957
|
| gptkbp:encodedBy |
IFN genes
|
| gptkbp:example |
gptkb:interferon_gamma
gptkb:interferon_beta interferon alpha interferon lambda |
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
immunomodulation
antiviral response inhibition of cell proliferation |
| gptkbp:halfLife |
several hours
|
| https://www.w3.org/2000/01/rdf-schema#label |
Interferons
|
| gptkbp:inducedBy |
expression of interferon-stimulated genes
|
| gptkbp:inhibitedBy |
viral replication
tumor cell growth |
| gptkbp:mechanismOfAction |
activation of immune cells
induction of antiviral proteins upregulation of MHC molecules |
| gptkbp:molecularWeight |
17-25 kDa
|
| gptkbp:producedBy |
gptkb:leukocytes
gptkb:natural_killer_cells gptkb:T_cells fibroblasts epithelial cells |
| gptkbp:promotion |
antigen presentation
macrophage activation natural killer cell activity |
| gptkbp:recipient |
gptkb:interferon_alpha/beta_receptor
interferon gamma receptor interferon lambda receptor |
| gptkbp:regulates |
immune response
|
| gptkbp:sideEffect |
gptkb:depression
gptkb:anemia fatigue flu-like symptoms |
| gptkbp:structure |
gptkb:protein
|
| gptkbp:type |
Type I interferon
Type II interferon Type III interferon |
| gptkbp:usedFor |
treatment of hepatitis C
treatment of multiple sclerosis treatment of hepatitis B treatment of some cancers |
| gptkbp:bfsParent |
gptkb:L03AB08
gptkb:L03AB13 |
| gptkbp:bfsLayer |
7
|