Inducible T-cell COStimulator (ICOS)

URI: https://gptkb.org/entity/Inducible_T-cell_COStimulator_(ICOS)
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:CD278
gptkbp:biologicalProcess receptor activity
immune system process
T cell costimulation
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy 1999
gptkbp:encodedBy gptkb:ICOS_gene
gptkbp:Entrez_Gene_ID 29851
ENSG00000163600
gptkbp:expressedIn lymphoid tissues
activated T cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of immune response
costimulatory molecule for T-cell activation
gptkbp:gene gptkb:ICOS
gptkbp:HGNC_ID HGNC:16902
https://www.w3.org/2000/01/rdf-schema#label Inducible T-cell COStimulator (ICOS)
gptkbp:interactsWith gptkb:PI3K
gptkb:Grb2
gptkbp:ligand ICOS ligand (ICOSL)
gptkbp:locatedOnChromosome chromosome 2
gptkbp:OMIM 604558
gptkbp:PDB 3U2S
gptkbp:proteinFamily gptkb:CD28_family
gptkbp:regulates cytokine production
T follicular helper cell development
gptkbp:role gptkb:cancer
autoimmune diseases
immunodeficiency
gptkbp:UniProtID Q9Y6Q6
gptkbp:bfsParent gptkb:JTX-2011
gptkb:CD275
gptkbp:bfsLayer 8