Idiopathic Parkinson disease

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease movement disorder
gptkbp:affects	substantia nigra
gptkbp:alsoKnownAs	gptkb:Parkinson's_disease
gptkbp:causedBy	unknown
gptkbp:characterizedBy	Lewy bodies loss of dopaminergic neurons
gptkbp:complication	gptkb:dementia gptkb:pneumonia falls autonomic dysfunction dysphagia
gptkbp:differentialDiagnosis	gptkb:corticobasal_degeneration gptkb:multiple_system_atrophy gptkb:progressive_supranuclear_palsy drug-induced parkinsonism
gptkbp:firstDescribed	gptkb:James_Parkinson 1817
gptkbp:hasGeneticComponent	possible
gptkbp:hasMotorSymptoms	true
gptkbp:hasNoCure	true
gptkbp:hasNonMotorSymptoms	true
gptkbp:hasOrphanetID	Parkinson disease: 411
gptkbp:hasTypicalOnsetAge	60 years
https://www.w3.org/2000/01/rdf-schema#label	Idiopathic Parkinson disease
gptkbp:ICD-10_code	gptkb:G20
gptkbp:isNotCausedBy	known genetic mutation
gptkbp:isSporadic	true
gptkbp:MeSH_ID	D010300
gptkbp:OMIM	168600
gptkbp:prevalence	1% of people over 60
gptkbp:progression	progressive chronic
gptkbp:riskFactor	age family history male sex
gptkbp:symptom	gptkb:depression bradykinesia postural instability rigidity shuffling gait tremor cognitive impairment masked facies micrographia
gptkbp:treatment	gptkb:levodopa MAO-B inhibitors deep brain stimulation dopamine agonists
gptkbp:bfsParent	gptkb:Parkinson_disease_(ORPHA:411)
gptkbp:bfsLayer	7