|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
recurrent bacterial infections
IRAK4 deficiency
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodedBy
|
IRAK4 gene
|
|
gptkbp:Entrez_Gene_ID
|
51135
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
various tissues
immune cells
|
|
gptkbp:fullName
|
Interleukin-1 receptor-associated kinase 4
|
|
gptkbp:function
|
serine/threonine-protein kinase
mediates signal transduction of interleukin-1 receptors
mediates signal transduction of Toll-like receptors
|
|
gptkbp:HGNC_ID
|
HGNC:17946
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IRAK4 protein
|
|
gptkbp:interactsWith
|
gptkb:Toll-like_receptors
gptkb:TRAF6
IRAK1
interleukin-1 receptor
MyD88
|
|
gptkbp:involvedIn
|
gptkb:NF-kappaB_signaling_pathway
inflammatory response
innate immune response
|
|
gptkbp:locatedOnChromosome
|
12q12
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
52 kDa
|
|
gptkbp:OMIM
|
606883
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Rattus norvegicus (rat)
|
|
gptkbp:PDB
|
2NRU
|
|
gptkbp:phosphorylates
|
itself (autophosphorylation)
IRAK1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:requires
|
TLR and IL-1R signaling
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:structure
|
contains a kinase domain
contains a death domain
|
|
gptkbp:UniProtID
|
Q9NWZ3
|
|
gptkbp:bfsParent
|
gptkb:KT-413
|
|
gptkbp:bfsLayer
|
8
|