|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
IKK-beta
IKK2
NFKBIKB
|
|
gptkbp:associatedWith
|
inflammatory diseases
immunodeficiency 40
|
|
gptkbp:component
|
gptkb:IKK_complex
|
|
gptkbp:discoveredBy
|
Yamaoka et al.
|
|
gptkbp:encodes
|
I-kappa-B kinase subunit beta
|
|
gptkbp:Entrez_Gene_ID
|
3551
ENSG00000104365
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
activates NF-kappa-B signaling pathway
phosphorylates I-kappa-B proteins
|
|
gptkbp:GO_term
|
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:5960
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IKBKB gene
|
|
gptkbp:interactsWith
|
gptkb:CHUK
gptkb:TRAF2
RELA
NEMO (IKBKG)
IKBKA
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.3
|
|
gptkbp:MIM_number
|
603258
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:OMIM
|
603258
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ikbkb
|
|
gptkbp:proteinFamily
|
serine/threonine-protein kinase
|
|
gptkbp:regulates
|
immune response
inflammatory response
|
|
gptkbp:UniProtID
|
O14920
|
|
gptkbp:bfsParent
|
gptkb:immunodeficiency_17
|
|
gptkbp:bfsLayer
|
8
|