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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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gptkb:HSPA1A
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gptkbp:encodedBy
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gptkb:HSPA1A_gene
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gptkbp:expressedIn
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many tissues
highly in testis
highly in leukocytes
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gptkbp:family
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gptkb:heat_shock_protein_70_family
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gptkbp:function
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protein folding
molecular chaperone
protection from stress
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gptkbp:GO_term
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gptkb:GO:0006457_(protein_folding)
GO:0009408 (response to heat)
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https://www.w3.org/2000/01/rdf-schema#label
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HSP70-1
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gptkbp:inducedBy
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heat shock
cellular stress
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gptkbp:interactsWith
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gptkb:BAG1
gptkb:HSP90
gptkb:HSP40
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gptkbp:length
|
641 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 6p21.3
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
|
70 kDa
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
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gptkbp:PDB
|
5BNQ
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gptkbp:postTranslationalModification
|
phosphorylation
acetylation
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gptkbp:role
|
neurodegenerative diseases
cancer progression
immune response
apoptosis regulation
protein homeostasis
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gptkbp:significance
|
target for cancer therapy
biomarker for stress
involved in autoimmune diseases
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gptkbp:structure
|
contains ATPase domain
contains substrate-binding domain
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gptkbp:UniProtID
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gptkb:P0DMV8
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gptkbp:bfsParent
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gptkb:P25445
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gptkbp:bfsLayer
|
7
|