regulators of G protein signaling (RGS proteins)
GPTKB entity
Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
Gα subunits
|
| gptkbp:discoveredBy |
David Siderovski
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:domain |
gptkb:RGS_domain
|
| gptkbp:example |
gptkb:RGS16
gptkb:RGS4 RGS10 RGS14 RGS17 RGS19 RGS2 RGS20 RGS22 RGS3 RGS5 RGS6 RGS7 RGS9 RGSZ1 RGSZ2 |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
act as GTPase-activating proteins (GAPs) for Gα subunits
regulate G protein-coupled receptor signaling |
| https://www.w3.org/2000/01/rdf-schema#label |
regulators of G protein signaling (RGS proteins)
|
| gptkbp:involvedIn |
gptkb:cancer
sensory perception immune response neuronal signaling metabolic regulation cardiovascular regulation |
| gptkbp:modulatedBy |
duration of G protein signaling
intensity of G protein signaling |
| gptkbp:proteinFamily |
RGS gene family
|
| gptkbp:regulates |
apoptosis
cell proliferation signal transduction synaptic transmission MAP kinase pathways adenylyl cyclase activity ion channel activity heterotrimeric G proteins GTP hydrolysis cardiac contractility second messenger systems vascular tone inflammatory responses phospholipase C activity receptor desensitization signal termination cellular responses to hormones and neurotransmitters |
| gptkbp:structure |
contain conserved RGS domain (~120 amino acids)
|
| gptkbp:target |
pharmacological research
|
| gptkbp:bfsParent |
gptkb:G_proteins
|
| gptkbp:bfsLayer |
6
|