|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
BMP-11
|
|
gptkbp:category
|
growth factor
secreted protein
|
|
gptkbp:discoveredBy
|
1999
|
|
gptkbp:Entrez_Gene_ID
|
10220
ENSG00000135414
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:nervous_system
gptkb:kidney
pancreas
|
|
gptkbp:family
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:fullName
|
Growth Differentiation Factor 11
|
|
gptkbp:function
|
regulation of embryonic development
regulation of neurogenesis
regulation of aging
regulation of skeletal development
|
|
gptkbp:gene
|
gptkb:GDF11
|
|
gptkbp:HGNC_ID
|
HGNC:4225
|
|
gptkbp:homologous_to
|
myostatin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GDF11 protein
|
|
gptkbp:inhibitedBy
|
muscle growth
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:molecularWeight
|
approximately 45 kDa
|
|
gptkbp:OMIM
|
605648
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
6B8Y
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:recipient
|
Activin type II receptors
|
|
gptkbp:regulates
|
muscle regeneration
pancreatic development
anterior-posterior patterning
olfactory neurogenesis
|
|
gptkbp:relatedTo
|
myostatin (GDF8)
|
|
gptkbp:reviewedBy
|
gptkb:Science_(journal)
gptkb:Cell_(journal)
gptkb:Nature_(journal)
|
|
gptkbp:role
|
potential role in age-related diseases
potential role in muscle regeneration
potential role in neurodegeneration
|
|
gptkbp:sequence
|
407 amino acids
|
|
gptkbp:structure
|
dimeric protein
|
|
gptkbp:symbol
|
gptkb:GDF11
|
|
gptkbp:UniProtID
|
O95390
|
|
gptkbp:bfsParent
|
gptkb:Elevian
|
|
gptkbp:bfsLayer
|
7
|