Formyl peptide receptor 1

URI: https://gptkb.org/entity/Formyl_peptide_receptor_1

GPTKB entity

Statements (49)

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:alias	gptkb:FPR gptkb:FMLP_receptor FPR1_HUMAN
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:chronic_granulomatous_disease gptkb:systemic_lupus_erythematosus sepsis
gptkbp:biologicalProcess	inflammatory response formyl peptide receptor activity cell chemotaxis
gptkbp:discoveredBy	1977
gptkbp:encodedBy	FPR1 gene
gptkbp:enemyOf	Cyclosporin H N-formyl peptides
gptkbp:Entrez_Gene_ID	2357
gptkbp:expressedIn	gptkb:leukocytes neutrophils
gptkbp:family	formyl peptide receptor family
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	involved in immune response binds N-formyl peptides mediates chemotaxis of neutrophils
gptkbp:gene	gptkb:FPR1
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	3826
https://www.w3.org/2000/01/rdf-schema#label	Formyl peptide receptor 1
gptkbp:interactsWith	gptkb:G_proteins beta-arrestins
gptkbp:length	350
gptkbp:ligand	N-formylmethionyl-leucyl-phenylalanine (fMLF)
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	gptkb:19q13.3
gptkbp:molecularWeight	38 kDa
gptkbp:OMIM	136537
gptkbp:orthologInMouse	gptkb:Fpr1
gptkbp:pathway	chemokine signaling pathway G protein-coupled receptor signaling pathway
gptkbp:PDB	6OMM
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:regulates	downregulated by anti-inflammatory cytokines upregulated by bacterial infection
gptkbp:structure	seven transmembrane domains
gptkbp:subcellularLocation	gptkb:plasma_membrane
gptkbp:UniProtID	gptkb:P21462
gptkbp:bfsParent	gptkb:FPR1
gptkbp:bfsLayer	8