Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:CD32B
IGFR2 Fc-gamma RII-b FcgRIIb |
| gptkbp:associatedWith |
gptkb:systemic_lupus_erythematosus
autoimmune diseases |
| gptkbp:biologicalProcess |
phagocytosis
transmembrane signaling receptor activity negative regulation of immune response antigen processing and presentation immunoglobulin binding |
| gptkbp:cellularComponent |
gptkb:plasma_membrane
|
| gptkbp:encodes |
Low affinity immunoglobulin gamma Fc region receptor II-b
|
| gptkbp:Entrez_Gene_ID |
2213
ENSG00000038274 |
| gptkbp:expressedIn |
gptkb:B_cells
dendritic cells macrophages monocytes |
| gptkbp:fullName |
Fc fragment of IgG receptor IIb
|
| gptkbp:function |
regulates immune response
inhibitory receptor for the Fc region of IgG |
| gptkbp:hasTranscriptVariant |
multiple transcript variants encoding different isoforms
|
| gptkbp:HGNC_ID |
3617
|
| https://www.w3.org/2000/01/rdf-schema#label |
FCGR2B
|
| gptkbp:locatedOnChromosome |
1
1q23.3 |
| gptkbp:mutationAssociatedWith |
increased susceptibility to autoimmune diseases
|
| gptkbp:OMIM |
147575
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Fcgr2b
|
| gptkbp:pathway |
immune system
Fc gamma R-mediated phagocytosis |
| gptkbp:product |
gptkb:CD32B
|
| gptkbp:proteinFamily |
gptkb:immunoglobulin_superfamily
gptkb:Fc_gamma_receptors |
| gptkbp:RefSeq |
NM_001002273
NM_001002274 NM_001002275 NM_001002276 NM_001002277 NM_001002278 NM_001002279 NM_001002280 NM_001002281 |
| gptkbp:regulates |
B cell activation
inflammatory response antibody production |
| gptkbp:UniProtID |
P31994
|
| gptkbp:bfsParent |
gptkb:CD32
gptkb:FCGR_genes |
| gptkbp:bfsLayer |
7
|