Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:CD32A
Fc-gamma RII-a FcgammaRIIA IGFR2 Immunoglobulin G Fc receptor II-a |
| gptkbp:associatedWith |
gptkb:systemic_lupus_erythematosus
autoimmune diseases idiopathic thrombocytopenic purpura |
| gptkbp:biologicalProcess |
immune response
inflammatory response immunoglobulin binding phagocytosis receptor activity regulation of immune complex clearance |
| gptkbp:cellularComponent |
gptkb:plasma_membrane
|
| gptkbp:discoveredBy |
genetic studies of immune receptors
|
| gptkbp:encodes |
Fc gamma receptor IIa protein
|
| gptkbp:Entrez_Gene_ID |
2212
ENSG00000143226 |
| gptkbp:expressedIn |
macrophages
platelets immune cells monocytes neutrophils |
| gptkbp:fullName |
Fc fragment of IgG receptor IIa
|
| gptkbp:function |
involved in immune response
mediates phagocytosis low affinity receptor for the Fc region of immunoglobulin gamma |
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasPolymorphism |
H131R
|
| gptkbp:hasTranscriptVariant |
multiple
|
| gptkbp:HGNC_ID |
3617
|
| https://www.w3.org/2000/01/rdf-schema#label |
FCGR2A
|
| gptkbp:interactsWith |
gptkb:IgG2
gptkb:IgG3 gptkb:IgG1 gptkb:IgG4 |
| gptkbp:locatedOnChromosome |
1q23
|
| gptkbp:mutationAssociatedWith |
alters susceptibility to infection
modifies risk of autoimmune disease |
| gptkbp:OMIM |
146790
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Fcgr2
|
| gptkbp:pathway |
immune system
innate immune system Fc gamma R-mediated phagocytosis |
| gptkbp:PDB |
3RY6
|
| gptkbp:product |
CD32a
|
| gptkbp:RefSeq |
NM_021642
|
| gptkbp:UniProtID |
P12318
|
| gptkbp:bfsParent |
gptkb:CD32
gptkb:FCGR_genes gptkb:chromosome_1q23 |
| gptkbp:bfsLayer |
7
|