|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ERG1
p55
ERG2
ERG3
ETS2-related gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Ewing's_sarcoma
gptkb:acute_myeloid_leukemia
prostate cancer
|
|
gptkbp:commonFusionPartner
|
TMPRSS2 gene
|
|
gptkbp:discoveredBy
|
Reddy et al.
|
|
gptkbp:encodes
|
ERG protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000157554
2078
|
|
gptkbp:expressedIn
|
hematopoietic cells
endothelial cells
|
|
gptkbp:firstDescribed
|
1987
|
|
gptkbp:fullName
|
gptkb:ETS-related_gene
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:fusionEvent
|
TMPRSS2-ERG fusion
|
|
gptkbp:HGNC_ID
|
gptkb:ERG
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERG gene
|
|
gptkbp:involvedIn
|
angiogenesis
regulation of gene expression
hematopoiesis
|
|
gptkbp:length
|
486 amino acids (canonical isoform)
|
|
gptkbp:locatedOnChromosome
|
chromosome 21
21q22.2
|
|
gptkbp:memberOf
|
gptkb:ETS_transcription_factor_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:gene
|
|
gptkbp:OMIM
|
165080
|
|
gptkbp:orthologInMouse
|
Erg gene
|
|
gptkbp:proteinFamily
|
gptkb:ETS_domain
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
vascular stability
|
|
gptkbp:transcriptionalRegulatorOf
|
gptkb:TIE2
gptkb:VEGF
ICAM2
endothelial-specific genes
|
|
gptkbp:UniProtID
|
P11308
|
|
gptkbp:bfsParent
|
gptkb:Fused_in_Sarcoma_protein
|
|
gptkbp:bfsLayer
|
7
|