Ewing's sarcoma

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:cancer
gptkb:disease
gptkbp:5YearSurvivalRate about 30% (metastatic)
about 70% (localized)
gptkbp:affects gptkb:bone
soft tissue
gptkbp:affiliatedWith gptkb:Ewing_family_of_tumors
gptkbp:causedBy genetic translocation
gptkbp:commonIn adolescents
children
gptkbp:diagnosedBy gptkb:X-rays
gptkb:CT_scan
MRI
biopsy
gptkbp:firstDescribed gptkb:James_Ewing
1921
gptkbp:formsFusionGeneWith gptkb:EWSR1-FLI1
gptkbp:hasNoKnown environmental cause
hereditary predisposition
https://www.w3.org/2000/01/rdf-schema#label Ewing's sarcoma
gptkbp:ICD-10_code C40
C41
gptkbp:incidence rare
about 3 cases per million per year
gptkbp:location gptkb:meat
gptkb:humerus
femur
pelvis
gptkbp:MeSH_ID D013545
gptkbp:mortalityRate high if metastatic
gptkbp:mostCommonTranslocation gptkb:t(11;22)(q24;q12)
gptkbp:OMIM 612219
gptkbp:originatedIn mesenchymal stem cell
neuroectodermal cell
gptkbp:prognosis metastasis
stage at diagnosis
tumor size
gptkbp:rareIn adults
gptkbp:relatedTo gptkb:PNET_(primitive_neuroectodermal_tumor)
gptkbp:riskFactor male sex
Caucasian ethnicity
age (childhood/adolescence)
gptkbp:symptom fever
pain
swelling
gptkbp:treatment surgery
radiation therapy
chemotherapy
gptkbp:bfsParent gptkb:Ewing_sarcoma
gptkbp:bfsLayer 6