Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:E6AP
|
| gptkbp:associatedWith |
gptkb:Angelman_syndrome
|
| gptkbp:discoveredBy |
Huibregtse JM et al.
|
| gptkbp:encodedBy |
gptkb:UBE3A_gene
|
| gptkbp:Entrez_Gene_ID |
7337
|
| gptkbp:enzymeClassification |
EC 6.3.2.19
|
| gptkbp:function |
gptkb:E3_ubiquitin-protein_ligase
|
| https://www.w3.org/2000/01/rdf-schema#label |
E6-Associated Protein
|
| gptkbp:interactsWith |
gptkb:HPV_E6_protein
|
| gptkbp:involvedIn |
gptkb:ubiquitin-proteasome_pathway
|
| gptkbp:locatedOnChromosome |
gptkb:15q11-q13
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
~100 kDa
|
| gptkbp:orthologInMouse |
gptkb:Ube3a
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:roleInCancer |
degradation of p53 tumor suppressor protein
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:UniProtID |
gptkb:Q05086
|
| gptkbp:bfsParent |
gptkb:E6AP
|
| gptkbp:bfsLayer |
8
|