RNA polymerase II
E561106
RNA polymerase II is the eukaryotic enzyme complex responsible for transcribing DNA into messenger RNA and many non-coding RNAs, playing a central role in gene expression.
All labels observed (3)
| Label | Occurrences |
|---|---|
| RNA polymerase II canonical | 2 |
| Mediator complex | 1 |
| RNAP II | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004988 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: RNA polymerase II Context triple: [FUS, interactsWith, RNA polymerase II]
-
A.
DNA ligase
DNA ligase is an essential enzyme that joins breaks in the sugar-phosphate backbone of DNA, enabling processes such as DNA replication and genetic recombination.
-
B.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
C.
DRNA
DRNA is the commonly used acronym for Puerto Rico’s Department of Natural and Environmental Resources, the government agency responsible for managing and protecting the island’s natural resources and environment.
-
D.
DNAA
DNAA is the ICAO airport code for Nnamdi Azikiwe International Airport, the main international gateway serving Abuja, Nigeria’s capital city.
-
E.
DNA
DNA is a major social-democratic political party in Norway, historically one of the country’s dominant governing parties.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: RNA polymerase II Target entity description: RNA polymerase II is the eukaryotic enzyme complex responsible for transcribing DNA into messenger RNA and many non-coding RNAs, playing a central role in gene expression.
-
A.
DNA ligase
DNA ligase is an essential enzyme that joins breaks in the sugar-phosphate backbone of DNA, enabling processes such as DNA replication and genetic recombination.
-
B.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
C.
DRNA
DRNA is the commonly used acronym for Puerto Rico’s Department of Natural and Environmental Resources, the government agency responsible for managing and protecting the island’s natural resources and environment.
-
D.
DNAA
DNAA is the ICAO airport code for Nnamdi Azikiwe International Airport, the main international gateway serving Abuja, Nigeria’s capital city.
-
E.
DNA
DNA is a major social-democratic political party in Norway, historically one of the country’s dominant governing parties.
- F. None of above. chosen
Statements (71)
| Predicate | Object |
|---|---|
| instanceOf |
DNA-directed RNA polymerase
ⓘ
eukaryotic RNA polymerase ⓘ multi-subunit enzyme complex ⓘ |
| alsoKnownAs |
Pol II
ⓘ
RNAP II ⓘ
linked to:
RNA polymerase II
|
| belongsTo | RNA polymerase II transcription machinery ⓘ |
| binds |
promoter DNA
ⓘ
ribonucleoside triphosphates ⓘ template strand of DNA ⓘ |
| catalyzes | formation of phosphodiester bonds in RNA ⓘ |
| evolutionarilyRelatedTo |
archaeal RNA polymerase
ⓘ
bacterial RNA polymerase core enzyme ⓘ |
| hasConsensusSequence | YSPTSPS in CTD repeats ⓘ |
| hasEnzymeCommissionNumber | EC 2.7.7.6 ⓘ |
| hasFunction |
DNA-dependent RNA synthesis
ⓘ
capping of nascent RNA via CTD recruitment ⓘ coupling transcription with 3′ end processing ⓘ coupling transcription with RNA splicing ⓘ gene expression regulation ⓘ mRNA synthesis ⓘ |
| hasMolecularFeature | C-terminal domain heptad repeats ⓘ |
| hasPart |
C-terminal domain of Rpb1
ⓘ
Rpb1 subunit ⓘ Rpb10 subunit ⓘ Rpb11 subunit ⓘ Rpb12 subunit ⓘ Rpb2 subunit ⓘ Rpb3 subunit ⓘ Rpb4 subunit ⓘ Rpb5 subunit ⓘ Rpb6 subunit ⓘ Rpb7 subunit ⓘ Rpb8 subunit ⓘ Rpb9 subunit ⓘ |
| hasProcess |
promoter clearance
ⓘ
transcription elongation ⓘ transcription initiation ⓘ transcription termination ⓘ |
| hasRoleIn |
cell cycle–regulated transcription
ⓘ
developmental gene regulation ⓘ stress response gene expression ⓘ |
| interactsWith |
DSIF complex
ⓘ
Mediator complex ⓘ NELF complex ⓘ TFIIB ⓘ TFIID ⓘ TFIIE ⓘ TFIIF ⓘ TFIIH ⓘ |
| isEncodedBy | multiple nuclear genes ⓘ |
| isEssentialFor | viability of most eukaryotic cells ⓘ |
| isInhibitedBy | alpha-amanitin ⓘ |
| isPresentIn |
animals
ⓘ
fungi ⓘ plants ⓘ protists ⓘ |
| isRegulatedBy |
CDK7 kinase
ⓘ
CDK9 kinase ⓘ CTD phosphorylation ⓘ Mediator complex ⓘ
linked to:
RNA polymerase II
general transcription factors ⓘ transcriptional activators ⓘ transcriptional repressors ⓘ |
| isTargetOf |
alpha-amanitin
ⓘ
linked to:
Claviceps
|
| occursIn |
archaeal cells (functional homologs)
ⓘ
eukaryotic nucleus ⓘ |
| transcribes |
long non-coding RNAs
ⓘ
many non-coding RNAs ⓘ messenger RNA ⓘ microRNA primary transcripts ⓘ small nuclear RNAs ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: RNA polymerase II Description of subject: RNA polymerase II is the eukaryotic enzyme complex responsible for transcribing DNA into messenger RNA and many non-coding RNAs, playing a central role in gene expression.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: RNA polymerase II
linked to: RNA polymerase II