EWSR1
E561108
EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
All labels observed (4)
| Label | Occurrences |
|---|---|
| EWS RNA-binding protein 1 | 1 |
| EWSR1 canonical | 1 |
| EWSR1–FLI1 | 1 |
| Ewing sarcoma breakpoint region 1 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004990 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: EWSR1 Context triple: [FUS, interactsWith, EWSR1]
-
A.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
B.
EWR
EWR is the three-letter IATA airport code for Newark Liberty International Airport, a major air travel hub serving the New York City metropolitan area.
-
C.
EWE
EWE is the National Rail station code for Ewell West railway station in Surrey, England.
-
D.
RSEQ
RSEQ is the governing body that organizes and oversees student sports and athletic competitions across Quebec’s educational institutions.
-
E.
ESR
ESR is the commonly used abbreviation for Eric S. Raymond, an influential American software developer and open-source advocate.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: EWSR1 Target entity description: EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
-
A.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
B.
EWR
EWR is the three-letter IATA airport code for Newark Liberty International Airport, a major air travel hub serving the New York City metropolitan area.
-
C.
EWE
EWE is the National Rail station code for Ewell West railway station in Surrey, England.
-
D.
RSEQ
RSEQ is the governing body that organizes and oversees student sports and athletic competitions across Quebec’s educational institutions.
-
E.
ESR
ESR is the commonly used abbreviation for Eric S. Raymond, an influential American software developer and open-source advocate.
- F. None of above. chosen
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
RNA-binding protein
ⓘ
gene ⓘ oncoprotein ⓘ protein ⓘ |
| alias |
EWS
ⓘ
Ewing sarcoma breakpoint region 1 ⓘ
linked to:
EWSR1
|
| associatedWith | phase separation and ribonucleoprotein granule formation ⓘ |
| bindsMolecule |
RNA
ⓘ
single-stranded DNA ⓘ |
| biologicalProcess |
DNA damage response
ⓘ
RNA processing ⓘ cell differentiation ⓘ mRNA splicing ⓘ pre-mRNA processing ⓘ transcription regulation ⓘ |
| canonicalFusion |
EWSR1–FLI1
ⓘ
linked to:
EWSR1
|
| canonicalFusionAssociatedDisease | Ewing sarcoma ⓘ |
| chromosomalBand | 22q12 ⓘ |
| family | FET protein family ⓘ |
| familyMemberWith |
FUS
ⓘ
TAF15 ⓘ |
| formsFusionWith |
ATF1
ⓘ
CREB1 ⓘ DDIT3 ⓘ ERG ⓘ FLI1 ⓘ NR4A3 ⓘ WT1 ⓘ |
| fullName |
EWS RNA-binding protein 1
ⓘ
linked to:
EWSR1
|
| geneID | NCBI Gene 2130 ⓘ |
| geneType | protein-coding gene ⓘ |
| interactsWith |
RNA polymerase II
ⓘ
splicing factors ⓘ |
| involvedInDisease |
Ewing sarcoma
ⓘ
acute myeloid leukemia ⓘ clear cell sarcoma ⓘ desmoplastic small round cell tumor ⓘ extraskeletal myxoid chondrosarcoma ⓘ myxoid liposarcoma ⓘ myxoid round cell liposarcoma ⓘ |
| locatedOnChromosome | human chromosome 22 ⓘ |
| molecularFunction |
DNA binding
ⓘ
RNA binding ⓘ transcriptional coactivator activity ⓘ |
| oncogenicMechanism | chromosomal translocation ⓘ |
| organism | Homo sapiens ⓘ |
| participatesIn | formation of aberrant transcription factors in cancer ⓘ |
| pathway |
RNA metabolism
ⓘ
transcription-coupled RNA processing ⓘ |
| postTranslationalModification |
arginine methylation
ⓘ
phosphorylation ⓘ |
| proteinDomain |
C-terminal RNA recognition motif
ⓘ
N-terminal low-complexity prion-like domain ⓘ RGG-rich regions ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
| uniprotID | P35663 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: EWSR1 Description of subject: EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.