CDK9 kinase
E1552442
UNEXPLORED
CDK9 kinase is a cyclin-dependent protein kinase that forms part of the P-TEFb complex and promotes transcription elongation by phosphorylating the C-terminal domain of RNA polymerase II.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CDK9 kinase canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22693390 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CDK9 kinase Context triple: [RNA polymerase II, isRegulatedBy, CDK9 kinase]
-
A.
CDK7 kinase
CDK7 kinase is a cyclin-dependent kinase that functions as a key regulator of transcription initiation and cell cycle control by phosphorylating the C-terminal domain of RNA polymerase II and activating other CDKs.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
D.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
E.
RET kinase
RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CDK9 kinase Target entity description: CDK9 kinase is a cyclin-dependent protein kinase that forms part of the P-TEFb complex and promotes transcription elongation by phosphorylating the C-terminal domain of RNA polymerase II.
-
A.
CDK7 kinase
CDK7 kinase is a cyclin-dependent kinase that functions as a key regulator of transcription initiation and cell cycle control by phosphorylating the C-terminal domain of RNA polymerase II and activating other CDKs.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
D.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
E.
RET kinase
RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.