Gemin2
E561085
Gemin2 is a core component of the SMN complex that plays a crucial role in the assembly of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
All labels observed (3)
| Label | Occurrences |
|---|---|
| Gemin2 canonical | 6 |
| GEMIN2 gene | 1 |
| gem-associated protein 2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004688 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Gemin2 Context triple: [Survival motor neuron protein, formsComplexWith, Gemin2]
-
A.
Gemini 2.0
Gemini 2.0 is a major updated release of Google’s multimodal AI model family, designed to provide more powerful and versatile capabilities across text, code, image, and other modalities.
-
B.
GEM
GEM is the Growth Enterprise Market board of the Hong Kong Stock Exchange, designed for smaller, high-growth and emerging companies to raise capital.
-
C.
Gemer
Gemer is a historical and geographical region in southern Slovakia known for its mining heritage, medieval castles, and karst landscapes.
-
D.
Gemini SC-4
Gemini SC-4 was the NASA spacecraft used for the Gemini 4 mission, which carried astronauts James McDivitt and Edward White on the first American spacewalk in 1965.
-
E.
GEM 63XL
The GEM 63XL is a solid rocket booster developed by Northrop Grumman to provide additional thrust for United Launch Alliance’s next-generation Vulcan launch vehicle.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Gemin2 Target entity description: Gemin2 is a core component of the SMN complex that plays a crucial role in the assembly of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
-
A.
Gemini 2.0
Gemini 2.0 is a major updated release of Google’s multimodal AI model family, designed to provide more powerful and versatile capabilities across text, code, image, and other modalities.
-
B.
GEM
GEM is the Growth Enterprise Market board of the Hong Kong Stock Exchange, designed for smaller, high-growth and emerging companies to raise capital.
-
C.
Gemer
Gemer is a historical and geographical region in southern Slovakia known for its mining heritage, medieval castles, and karst landscapes.
-
D.
Gemini SC-4
Gemini SC-4 was the NASA spacecraft used for the Gemini 4 mission, which carried astronauts James McDivitt and Edward White on the first American spacewalk in 1965.
-
E.
GEM 63XL
The GEM 63XL is a solid rocket booster developed by Northrop Grumman to provide additional thrust for United Launch Alliance’s next-generation Vulcan launch vehicle.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
SMN complex component
ⓘ
protein ⓘ |
| alternativeName |
SIP1
ⓘ
gem-associated protein 2 ⓘ
linked to:
Gemin2
|
| associatedWith | spinal muscular atrophy pathway ⓘ |
| binds | SMN Tudor domain-containing region ⓘ |
| biologicalProcess |
RNP complex biogenesis
ⓘ
U snRNP biogenesis ⓘ mRNA processing ⓘ pre-mRNA splicing ⓘ regulation of RNA splicing ⓘ small nuclear RNA processing ⓘ snRNP assembly ⓘ spliceosomal snRNP complex assembly ⓘ |
| cellularComponent |
Cajal body
ⓘ
linked to:
Cajal bodies
cytoplasm ⓘ germ cell granule ⓘ nucleus ⓘ |
| chromosomalLocation | human chromosome 14q21 ⓘ |
| conservedIn | eukaryotes ⓘ |
| encodedBy |
GEMIN2 gene
ⓘ
linked to:
Gemin2
|
| foundInTaxon | Homo sapiens ⓘ |
| hasDomain | coiled-coil region ⓘ |
| interactsWith |
Gemin3
ⓘ
Gemin4 ⓘ SMN protein ⓘ
linked to:
survival motor neuron protein
Sm proteins ⓘ small nuclear RNAs ⓘ |
| involvedInComplexAssembly | Sm core assembly on snRNA ⓘ |
| isEssentialFor | snRNP biogenesis in metazoans ⓘ |
| length | 280 amino acids (human) ⓘ |
| localization | nuclear gems ⓘ |
| molecularFunction |
RNA binding
ⓘ
protein binding ⓘ |
| orthologIn |
Caenorhabditis elegans
ⓘ
Drosophila melanogaster ⓘ Mus musculus ⓘ |
| partOf | SMN complex ⓘ |
| regulates | snRNP core particle formation ⓘ |
| requiredFor | efficient spliceosome assembly ⓘ |
| roleIn |
assembly of small nuclear ribonucleoproteins
ⓘ
spliceosome function ⓘ |
| stabilizes | SMN complex ⓘ |
| subunitOf |
survival motor neuron (SMN) complex
ⓘ
linked to:
SMN complex
|
| uniprotId | Q9H840 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Gemin2 Description of subject: Gemin2 is a core component of the SMN complex that plays a crucial role in the assembly of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
Referenced by (8)
Full triples — surface form annotated when it differs from this entity's canonical label.